Chemical stability of tramadol hydrochloride injection admixed with selected pain drugs
نویسندگان
چکیده
منابع مشابه
Compatibility of tramadol hydrochloride injection with selected drugs and solutions.
T ramadol hydrochloride is a centrally acting synthetic analgesic with a dual mechanism of action. Tramadol and its Odesmethyl metabolite (M1) bind to opioid receptors, with M1 having a 200-fold higher affinity for binding to these receptors. Tramadol has also been shown to inhibit the uptake of norepinephrine and serotonin, suggesting that its antinociceptive activity is mediated by both opioi...
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Neurokinin-1 receptor antagonist, 5-hydroxytryptamine-3 RA, and dexamethasone combination therapy is standard of care for the prevention of chemotherapy-induced nausea and vomiting. Herein we describe the physical and chemical stability of rolapitant injectable emulsion 166.5 mg in 92.5 mL (185 mg hydrochloride salt) admixed with palonosetron injection 0.25 mg in 5 mL (0.28 mg hydrochloride sal...
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Propofol is frequently associated with pain on injection. We evaluated the effect of tramadol in a randomised, double-blind study using a tourniquet venous retention technique. Normal saline placebo was given intravenously to patients in Group 1 (n = 30),tramadol 50 mg to Group 2 (n = 30), and lignocaine 50 mg to Group 3 (n = 30). The venous retention of drugs was maintained for 1 minute, follo...
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Aim of the study: To compare efficacy of tramadol injection as an opioid analgesia versus epidural analgesia on governing labor pain, progress and outcomes (maternal and fetal). Duration and place of study: Department of Obstetrics and Gynecology Zagazig University from November 2011 to December 2013. Methodology: One hundred fifty pregnant women primigravida had gestational age between 37 to 4...
متن کاملStability of tramadol with three 5-HT3 receptor antagonists in polyolefin bags for patient-controlled delivery systems
BACKGROUND Mixing 5-hydroxytryptamine-3 (5-HT3) receptor antagonists with patient-controlled analgesia (PCA) solutions of tramadol has been shown to decrease the incidence of nausea and vomiting associated with the use of tramadol PCA for postoperative pain. However, such mixtures are not commercially available, and the stability of the drug combinations has not been duly studied. The study aim...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Investigation
سال: 2011
ISSN: 2230-973X
DOI: 10.4103/2230-973x.76729